Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis

MeSH terms

• Acetates / chemistry
• Acetates / pharmacology
• Acetates / therapeutic use
• Animals
• Asthma / drug therapy*
• Asthma / metabolism
• Aza Compounds / chemistry
• Aza Compounds / pharmacology
• Aza Compounds / therapeutic use
• Carbazoles / chemistry
• Carbazoles / pharmacology
• Carbazoles / therapeutic use
• Clinical Trials as Topic
• Humans
• Indoleacetic Acids / chemistry
• Indoleacetic Acids / pharmacology
• Indoleacetic Acids / therapeutic use
• Pyrazoles / chemistry
• Pyrazoles / therapeutic use
• Pyrimidines / chemistry
• Pyrimidines / therapeutic use
• Pyrroles / chemistry
• Pyrroles / pharmacology
• Pyrroles / therapeutic use
• Receptors, Immunologic / antagonists & inhibitors*
• Receptors, Immunologic / metabolism
• Receptors, Prostaglandin / antagonists & inhibitors*
• Receptors, Prostaglandin / metabolism
• Rhinitis, Allergic, Perennial / drug therapy*
• Rhinitis, Allergic, Perennial / immunology
• Rhinitis, Allergic, Perennial / metabolism
• Rhinitis, Allergic, Seasonal / drug therapy*
• Rhinitis, Allergic, Seasonal / immunology
• Rhinitis, Allergic, Seasonal / metabolism
• Sulfonamides / chemistry
• Sulfonamides / pharmacology
• Sulfonamides / therapeutic use
• Th2 Cells / metabolism*
• Thiazoles / chemistry
• Thiazoles / therapeutic use